Author's response to reviews Title:Hepatitis B Spliced Protein (HBSP) Promotes the Carcinogenic Effects of Benzo [alpha] pyrene by Interacting with Microsomal Epoxide Hydrolase and Enhancing Its Hydrolysis Activity Authors:
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The manuscript has been carefully reviewed and further edited, mainly literally, by a native-English speaker with scientific expertise. We also made a number of formatting changes as such that of “References” to strictly conform to the journal’s formatting requirements. We believe that in the revised manuscript the usage of English language and appearance of formats are appropriate for publication. For ease of your review, all the minor literal corrections and formatting changes have been omitted in the new “clean” edition by enforcing “Accepted All Changes”.
منابع مشابه
Effect of dietary clofibrate on epoxide hydrolase activity in tissues of mice.
The effects of dietary clofibrate on the epoxide-metabolizing enzymes of mouse liver, kidney, lung and testis were evaluated using trans-stilbene oxide as a selective substrate for the cytosolic epoxide hydrolase, cis-stilbene oxide and benzo[a]pyrene 4,5-oxide as substrates for the microsomal form, and cis-stilbene oxide as a substrate for glutathione S-transferase activity. The hydration of t...
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The potential of polycyclic aromatic hydrocarbons (PAHs) to modulate microsomal epoxide hydrolase activity, determined using benzo[a]pyrene 5-oxide as substrate, in human liver, was evaluated and compared to rat liver. Precision-cut liver slices prepared from fresh human liver were incubated with six structurally diverse PAHs, at a range of concentrations, for 24h. Of the six PAHs studied, benz...
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The mutagenic and carcinogenic metabolite of benzo[a]pyrene, (7R,8S)-dihydroxy-(9R,10R)-epoxy-7,8, 9,10-tetrahydrobenzo[a]pyrene, undergoes two major reactions in the presence of DNA: (i) hydrolysis and (ii) covalent binding. We report that hydrolysis and covalent binding are specific and general acid-catalyzed reactions with the same or similar rate-determining steps. To account for the simila...
متن کاملCharacterization of Microsomal Epoxide Hydrolase in Hyperplastic Liver Nodules of Rats1
Microsomal epoxide hydrolase, a major antigenic marker of putative preneoplastic hepatocytes was studied in hyperplastic liver nodules and in normal liver tissue. Hyperplastic nodules induced by two different protocols contained 2to 3-fold higher specific activities of microsomal epoxide hydrolase than did normal surrounding tissue. However, no increase in cytosolic epoxide hydrolase determined...
متن کاملCharacterization of microsomal epoxide hydrolase in hyperplastic liver nodules of rats.
Microsomal epoxide hydrolase, a major antigenic marker of putative preneoplastic hepatocytes was studied in hyperplastic liver nodules and in normal liver tissue. Hyperplastic nodules induced by two different protocols contained 2to 3-fold higher specific activities of microsomal epoxide hydrolase than did normal surrounding tissue. However, no increase in cytosolic epoxide hydrolase determined...
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تاریخ انتشار 2013